Julkaistu 6.5.2022

METin syöpäseminaarissa vieraana Masanobu Komatsu 19.5. klo 15

Tampereen yliopiston lääketieteen ja terveysteknologian tiedekunnan (MET) syöpäseminaarissa torstaina 19.5. kello 15-16 kuullaan puheenvuoro Johns Hopkinsin yliopistosta ja lastensairaalasta Yhdysvalloista.

Apulaisprofessori Masanobu Komatsun otsikkona on "Gateway to TLS: Blood vessels within tertiary lymphoid structure may hold the key to ending the war on cancer".

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Gateway to TLS:  Blood vessels within tertiary lymphoid structure may hold the key to ending the war on cancer

Associate Professor, Masanobu Komatsu, Ph.D.
Johns Hopkins School of Medicine and Johns Hopkins All Children’s Hospital, USA

Abstract:

Clinical evidence indicates that the occurrence of tertiary lymphoid structures (TLS) in tumors is associated with patients' response to immune checkpoint blockade therapies and cancer survival. 

TLS are dense clusters of immune cells that contain T cells, B cells, and dendritic cells surrounding high endothelial venules (HEVs).  HEVs are venules specialized for recruiting T cells and B cells from the circulation.  It is thought that TLS are the recruitment centers for T cells and B cells where these adaptive immune cells become activated locally by tumor antigens, and the HEVs serve as the main gateways for the recruitment. 

We investigated the molecular signature of intratumoral HEVs to better understand these functionally unique blood vessels and explored a therapeutic strategy to induce TLS formation in tumors to enhance anti-tumor immunity and heighten the efficacy of cancer therapies.